Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 1/20 | 0.60 |
| ▸ | GABRD | O14764 | 1/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.60 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.60 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.60 |
| ▸ | GABRE | P78334 | 1/20 | 0.60 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.60 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.60 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.60 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10989791 | 0.93 | ALDH1A1 (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL11244564 | 0.86 | GABRP (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Dibenzothiophene SCHEMBL28899929 | 0.85 | KMT2A (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL29501103 | 0.85 | ALDH1A1 (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL51409 | 0.85 | ALDH1A1 (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL11243525 | 0.84 | CA12 (0.49) | SMN1; SMN2ALDH1A1MAPTRAB9AHCRTR1 | |
| SCHEMBL11247750 | 0.84 | LMNA (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL31544289 | 0.83 | HCRTR1 (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Hydrochloric Acid SCHEMBL11231115 | 0.83 | LMNA (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL19612305 | 0.83 | ALDH1A1 (0.47) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4334078-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATICS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-08 | — | — | US | disclosed |
| US-4219657-A | USED AS ANTIINFLAMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1980-08-26 | — | — | US | disclosed |