Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 18/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11108319 | 0.91 | ELANE (0.44) | ELANEALDH1A1LMNACYP3A4HIF1A | |
| SCHEMBL9370693 | 0.79 | ELANE (0.45) | ELANE | |
| SCHEMBL1451808 | 0.79 | KDM4E (0.44) | ALDH1A1LMNA | |
| SCHEMBL29607284 | 0.76 | ELANE (0.74) | ELANEALDH1A1LMNACYP3A4HIF1A | |
| SCHEMBL2471671 | 0.75 | ELANE (0.64) | ELANE | |
| SCHEMBL11422532 | 0.75 | MEN1 (0.38) | — | |
| SCHEMBL11259665 | 0.74 | ALDH1A1 (0.44) | ELANEALDH1A1LMNACYP3A4HIF1A | |
| SCHEMBL7219935 | 0.73 | ELANE (0.52) | ELANE | |
| SCHEMBL5468257 | 0.71 | ALDH1A1 (0.40) | ELANEALDH1A1LMNACYP3A4 | |
| SCHEMBL11250507 | 0.71 | ALOX15 (0.49) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0019411-B1 | 1-PHENYL-2-AMINOETHANOL DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS THEREOF | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-12-22 | — | — | EP | claimed |
| US-4323575-A | TOPICAL ANTIINFLAMMATORY AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-04-06 | — | — | US | claimed |
| EP-0019411-A1 | 1-Phenyl-2-aminoethanol derivatives, processes for their manufacture and pharmaceutical compositions thereof | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-11-26 | — | — | EP | claimed |
| US-4323575-A | TOPICAL ANTIINFLAMMATORY AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-04-06 | — | — | US | disclosed |
| EP-0006298-B1 | ANTI-INFLAMMATORY 1-PHENYL-2-AMINOETHANOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF FOR TOPICAL USE, AND PROCESSES FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-03-31 | — | — | EP | disclosed |
| US-4303649-A | ANTIINFLAMMATORY AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-12-01 | — | — | US | disclosed |
| EP-0019411-A1 | 1-Phenyl-2-aminoethanol derivatives, processes for their manufacture and pharmaceutical compositions thereof | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-11-26 | — | — | EP | disclosed |