SCHEMBL11245609

SCHEMBL11245609

CCOC(=O)Cc1c(-c2ccccc2)nn(-c2ccccc2)c1-c1ccc(OC)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.48
NPSR1 Q6W5P4 1/20 0.48
GSK3B P49841 4/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
KDM4E B2RXH2 2/20 0.47
HPGD P15428 1/20 0.47
RECQL P46063 1/20 0.47
KMT2A Q03164 1/20 0.47
LMNA P02545 1/20 0.46
HTT P42858 1/20 0.46
GABRA2 P47869 1/20 0.46
GABRB2 P47870 1/20 0.46
TP53 P04637 1/20 0.45
TSHR P16473 1/20 0.45
HSD17B10 Q99714 1/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
GAA P10253 1/20 0.45
ATM Q13315 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11248919 0.88 PTGDR2 (0.50) ALDH1A1NPSR1KDM4EKMT2ALMNA
SCHEMBL11242309 0.87 SLC2A2 (0.51) ALDH1A1NPSR1CYP3A4CYP2C9CYP2C19
SCHEMBL11251973 0.84 RPA1 (0.50) ALDH1A1NPSR1CYP3A4CYP2C9CYP2C19
SCHEMBL4161662 0.83 MEN1 (0.54) ALDH1A1NPSR1CYP3A4CYP2C9CYP2C19
SCHEMBL11240983 0.83 KMT2A (0.52) ALDH1A1NPSR1CYP3A4CYP2C9CYP2C19
SCHEMBL7995963 0.81 PTGS1 (0.52) ALDH1A1NPSR1CYP3A4CYP2C9CYP2C19
SCHEMBL11731366 0.80 HPGD (0.54) ALDH1A1NPSR1CYP2C9CYP2C19KDM4E
SCHEMBL6123566 0.80 ALDH1A1 (0.61) ALDH1A1NPSR1GSK3BCYP3A4CYP2C9
SCHEMBL1997120 0.80 ALDH1A1 (0.53) ALDH1A1NPSR1CYP3A4CYP2C9CYP2C19
SCHEMBL11247071 0.80 KMT2A (0.49) ALDH1A1NPSR1KMT2ALMNAFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4325962-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIDYRETICS BYK-GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1982-04-20 US disclosed
US-4146721-A ANALGESICS, ANTIINFLAMMATORY AGENTS AND ANTIPYRETICS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1979-03-27 US disclosed