Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237436 | 0.92 | HMOX1 (0.52) | HMOX1CYP11B1CYP11B2 | |
| SCHEMBL11233927 | 0.89 | HMOX1 (0.49) | HMOX1KDM4EALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL11233061 | 0.89 | HMOX1 (0.56) | HMOX1 | |
| SCHEMBL11239249 | 0.84 | HMOX1 (0.41) | HMOX1KDM4EALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL11243031 | 0.83 | HMOX1 (0.53) | HMOX1CYP11B1CYP11B2 | |
| SCHEMBL11235610 | 0.83 | HMOX1 (0.66) | HMOX1 | |
| SCHEMBL11240321 | 0.82 | HMOX1 (0.52) | HMOX1 | |
| SCHEMBL11246479 | 0.82 | ALDH1A1 (0.39) | HMOX1KDM4EALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL11241840 | 0.81 | HMOX1 (0.58) | HMOX1CYP11B1CYP11B2 | |
| SCHEMBL11238541 | 0.81 | ALDH1A1 (0.39) | KDM4EALDH1A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |