Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246479 | 0.95 | ALDH1A1 (0.39) | HMOX1ALDH1A1KDM4ECYP11B1CYP11B2 | |
| SCHEMBL11243887 | 0.91 | CYP11B1 (0.49) | HMOX1CYP11B1CYP11B2KMT2A | |
| SCHEMBL11238541 | 0.89 | ALDH1A1 (0.39) | ALDH1A1KDM4ECYP11B1CYP11B2KMT2A | |
| SCHEMBL11233199 | 0.88 | CYP11B1 (0.52) | HMOX1ALDH1A1KDM4ECYP11B1CYP11B2 | |
| SCHEMBL11235766 | 0.87 | ALDH1A1 (0.37) | ALDH1A1KDM4ECYP11B1CYP11B2KMT2A | |
| SCHEMBL11239019 | 0.87 | HMOX1 (0.48) | HMOX1CYP11B1CYP11B2 | |
| SCHEMBL11246523 | 0.86 | ALDH1A1 (0.37) | ALDH1A1KDM4ECYP11B1CYP11B2KMT2A | |
| SCHEMBL11240528 | 0.86 | CYP11B1 (0.47) | HMOX1CYP11B1CYP11B2KMT2A | |
| SCHEMBL11245667 | 0.84 | HMOX1 (0.49) | HMOX1ALDH1A1KDM4ECYP11B1CYP11B2 | |
| SCHEMBL11231027 | 0.83 | CYP11B1 (0.50) | HMOX1ALDH1A1KDM4ECYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049565-A2 | Derivatives of substituted N-alkylimidazoles, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4321272-A | Derivatives of substituted N-alkylimidazoles | SYNTEX (U.S.A.) INC. (US) | 1982-03-23 | — | — | US | disclosed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |