Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11227756 | 0.80 | ALDH1A1 (0.57) | PTGS1PTGS2MKNK1MKNK2CYP11B2 | |
| SCHEMBL17067677 | 0.80 | KDM4E (0.42) | PTGS1PTGS2CYP11B2CYP11B1DHODH | |
| SCHEMBL17067049 | 0.79 | EIF4E (0.50) | PTGS1PTGS2MKNK1MKNK2CYP11B2 | |
| SCHEMBL11157927 | 0.78 | MKNK1 (0.56) | PTGS1PTGS2MKNK1MKNK2EIF4E | |
| SCHEMBL11235175 | 0.78 | PTGS1 (0.45) | PTGS1PTGS2MKNK1MKNK2PDE10A | |
| SCHEMBL17067680 | 0.78 | CYP11B2 (0.54) | PTGS1PTGS2CYP11B2PDE2APDE10A | |
| SCHEMBL20371666 | 0.77 | MKNK1 (0.57) | PTGS1PTGS2MKNK1MKNK2PDE2A | |
| SCHEMBL11231194 | 0.76 | CYP2A6 (0.53) | PTGS1PTGS2MKNK1MKNK2PDE10A | |
| SCHEMBL15730180 | 0.75 | MKNK1 (0.47) | PTGS1PTGS2MKNK1MKNK2CYP11B2 | |
| SCHEMBL15730119 | 0.75 | MKNK1 (0.44) | PTGS1PTGS2MKNK1MKNK2PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |