Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | DRD4 | P21917 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245536 | 0.91 | HRH1 (0.42) | HRH1HTR2AHRH4DRD2DRD4 | |
| SCHEMBL11248154 | 0.83 | SLC6A2 (0.42) | HRH1HTR2AHRH4DRD2DRD4 | |
| SCHEMBL11248897 | 0.82 | HRH1 (0.56) | HRH1HTR2AHRH4DRD2DRD4 | |
| SCHEMBL7681805 | 0.82 | HRH4 (0.45) | HRH1HTR2AHRH4DRD2DRD4 | |
| Bromide SCHEMBL11473841 | 0.81 | HRH1 (0.56) | HRH1HTR2AHRH4DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL11400430 | 0.81 | HRH4 (0.44) | HRH1HTR2AHRH4DRD2DRD4 | |
| SCHEMBL11242210 | 0.77 | HRH1 (0.41) | HRH1HTR2AHRH4DRD2DRD4 | |
| SCHEMBL7674579 | 0.76 | DRD2 (0.47) | HRH1HTR2AHRH4DRD2DRD4 | |
| SCHEMBL11244787 | 0.75 | HTR2A (0.43) | HRH1HTR2AHRH4DRD2DRD4 | |
| Bromide SCHEMBL11309721 | 0.74 | HTR2A (0.42) | HRH1HTR2AHRH4DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016261-B1 | SPIRO(DIBENZ(B,F)OXEPIN-PIPERIDINES) AND METHODS OF PREPARING SAME | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-12-29 | — | — | EP | disclosed |