SCHEMBL11246302

SCHEMBL11246302

COc1cc2c(cc1OC)C(=O)c1c(N)ccc(N)c1C2=O

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.66
ADORA2A P29274 4/20 0.66
MEN1 O00255 4/20 0.66
KMT2A Q03164 4/20 0.66
MAPT P10636 4/20 0.66
POLB P06746 3/20 0.66
THRB P10828 2/20 0.66
SMN1; SMN2 Q16637 2/20 0.66
FGB P02675 1/20 0.66
MAPK1 P28482 1/20 0.66
PPARG P37231 1/20 0.66
RAB9A P51151 1/20 0.66
NCOA2 Q15596 1/20 0.66
NCOA1 Q15788 1/20 0.66
NPSR1 Q6W5P4 1/20 0.66
CSNK1A1 P48729 2/20 0.52
CSNK1D P48730 2/20 0.52
CSNK1G1 Q9HCP0 2/20 0.52
FGR P09769 1/20 0.52
PIM1 P11309 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2303569 0.79 MAPT (1.00) ALDH1A1ADORA2AMEN1KMT2AMAPT
SCHEMBL498594 0.79 ALDH1A1 (0.76) ALDH1A1ADORA2AMEN1KMT2AMAPT
SCHEMBL498449 0.79 ALDH1A1 (0.76) ALDH1A1ADORA2AMEN1KMT2AMAPT
SCHEMBL11243983 0.79 ALDH1A1 (0.76) ALDH1A1ADORA2AMEN1KMT2AMAPT
SCHEMBL18048115 0.78 CA1 (0.56) ALDH1A1MEN1KMT2AMAPTPOLB
SCHEMBL31369142 0.78 CA1 (0.56) ALDH1A1MEN1KMT2AMAPTPOLB
SCHEMBL498666 0.75 MEN1 (0.79) ALDH1A1ADORA2AMEN1KMT2AMAPT
SCHEMBL3909101 0.75 MAPT (0.64) ALDH1A1ADORA2AMEN1KMT2AMAPT
SCHEMBL3899483 0.75 CA1 (0.54) ALDH1A1MEN1KMT2AMAPTPOLB
SCHEMBL28575367 0.75 CA1 (0.54) ALDH1A1MEN1KMT2AMAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0025926-B1 PROCESS FOR THE PREPARATION OF MONOAROYLATED 1,4-DIAMINO ANTHRAQUINONES BAYER AG (DE) 1982-11-24 EP disclosed
US-4324732-A IN PRESENCE OF TERITIARY ALIPHATIC AMINOALCOHOL AND/OR QUARTERNARY AMMONIUM COMPOUND BAYER AKTIENGESELLSCHAFT (DE) 1982-04-13 US disclosed
EP-0025926-A1 Process for the preparation of monoaroylated 1,4-diamino anthraquinones BAYER AG (DE) 1981-04-01 EP disclosed