Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243420 | 0.84 | HTR1A (0.69) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| Hydrochloric Acid SCHEMBL11224419 | 0.83 | HTR1A (0.68) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL11347103 | 0.83 | MTNR1A (0.48) | MEN1KMT2A | |
| SCHEMBL11242128 | 0.83 | SIGMAR1 (0.51) | HTR1ASIGMAR1MEN1TP53CYP1A2 | |
| SCHEMBL11351695 | 0.82 | HTR1A (0.60) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL11226385 | 0.78 | SIGMAR1 (0.50) | HTR1ASIGMAR1MEN1TP53CYP1A2 | |
| SCHEMBL11227428 | 0.78 | SIGMAR1 (0.50) | HTR1ASIGMAR1MEN1TP53CYP1A2 | |
| SCHEMBL11249534 | 0.78 | SIGMAR1 (0.50) | HTR1ASIGMAR1MEN1TP53CYP1A2 | |
| SCHEMBL11243577 | 0.78 | SIGMAR1 (0.52) | HTR1ASIGMAR1MEN1TP53CYP1A2 | |
| SCHEMBL11226424 | 0.78 | SIGMAR1 (0.52) | SIGMAR1MEN1TP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |