Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 6/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.36 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.35 |
| ▸ | OSBP | P22059 | 2/20 | 0.35 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246664 | 0.85 | SRD5A2 (0.48) | SRD5A2GPBAR1SRD5A1NPC1L1OSBP | |
| SCHEMBL11237662 | 0.74 | SRD5A2 (0.35) | SRD5A2SRD5A1 | |
| SCHEMBL11237658 | 0.74 | SRD5A2 (0.35) | SRD5A2SRD5A1 | |
| SCHEMBL11250190 | 0.72 | NPC1L1 (0.68) | GPBAR1NPC1L1MEN1LMNAKMT2A | |
| SCHEMBL11240576 | 0.72 | GPBAR1 (0.45) | SRD5A2GPBAR1SRD5A1NPC1L1AKR1B10 | |
| SCHEMBL16846107 | 0.71 | SRD5A2 (0.51) | SRD5A2GPBAR1SRD5A1LMNA | |
| SCHEMBL9348309 | 0.71 | SRD5A2 (0.51) | SRD5A2GPBAR1SRD5A1NPC1L1OSBP | |
| SCHEMBL9348037 | 0.69 | SRD5A2 (0.51) | SRD5A2GPBAR1SRD5A1NPC1L1OSBP | |
| SCHEMBL9822569 | 0.69 | SRD5A2 (0.74) | SRD5A2GPBAR1SRD5A1AKR1B10AKR1B1 | |
| SCHEMBL9782796 | 0.68 | SRD5A2 (0.59) | SRD5A2GPBAR1SRD5A1NPC1L1NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317817-A | SKIN DISORDERS; ACEME; ENZYME INHIBITORS | RICHARDSON-MERRELL INC. (US) | 1982-03-02 | — | — | US | disclosed |