Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.63 |
| ▸ | BACE1 | P56817 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 2/20 | 0.55 |
| ▸ | PPARA | Q07869 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.54 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707281 | 0.84 | ALOX5 (0.64) | GSK3BBACE1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9344834 | 0.82 | GSK3B (0.76) | GSK3BBACE1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9344837 | 0.82 | GSK3B (0.76) | GSK3BBACE1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7999149 | 0.82 | GSK3B (0.83) | GSK3BBACE1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7999153 | 0.82 | GSK3B (0.83) | GSK3BBACE1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10953300 | 0.80 | GSK3B (0.63) | GSK3BBACE1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10953297 | 0.80 | GSK3B (0.63) | GSK3BBACE1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL827256 | 0.79 | PAM (0.70) | NPC1SMN1; SMN2MAOBMAPT | |
| SCHEMBL827257 | 0.79 | PAM (0.70) | NPC1SMN1; SMN2MAOBMAPT | |
| SCHEMBL20024692 | 0.79 | LCK (0.77) | GSK3BBACE1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023385-B1 | ETHANAMINE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1982-12-15 | — | — | EP | disclosed |
| US-4338333-A | ANTIOBESITY, HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1982-07-06 | — | — | US | disclosed |
| EP-0023385-A1 | Ethanamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-02-04 | — | — | EP | disclosed |