Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244168 | 0.95 | ADRB1 (0.46) | OPRM1OPRD1OPRK1ADRB1LMNA | |
| SCHEMBL3434728 | 0.93 | ADRB1 (0.49) | OPRM1OPRD1OPRK1ADRB1LMNA | |
| SCHEMBL7303225 | 0.79 | ADRB1 (0.41) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| SCHEMBL1422064 | 0.79 | ADRB1 (0.49) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| SCHEMBL11250117 | 0.78 | PARP15 (0.46) | ADRB1ADRB2 | |
| SCHEMBL11249305 | 0.78 | ADRB1 (0.46) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| SCHEMBL11249303 | 0.77 | HRH3 (0.51) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| SCHEMBL27994907 | 0.77 | DRD2 (0.55) | OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL9686027 | 0.77 | ADRB1 (0.40) | ADRB1LMNACYP2D6MEN1CYP1A2 | |
| SCHEMBL8389404 | 0.77 | ESR1 (0.65) | LMNAKMT2ABLMTMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4311708-A | ADRENERGIC BLOCKING AGENTS | SYNTHELABO (FR) | 1982-01-19 | — | — | US | disclosed |
| US-4252984-A | 1-/P-/2-/CYCLOPROPYLMETHOXY/ETHYL/PHENOXY/-3-ISOPROPYLAMINO-2 -PROPANOL | SYNTHELABO (FR) | 1981-02-24 | — | — | US | disclosed |