Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.77 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.77 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.77 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.77 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.77 |
| ▸ | ACHE | P22303 | 14/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.77 |
| ▸ | ATP4A | P20648 | 1/20 | 0.77 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.77 |
| ▸ | HRH2 | P25021 | 1/20 | 0.77 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.77 |
| ▸ | ATP4B | P51164 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL11248317 | 1.00 | ACHE (0.77) | ACHEMEN1SLC22A1ABCB11LMNA | |
| SCHEMBL11250179 | 0.97 | ACHE (0.82) | ACHEMEN1SLC22A1ABCB11LMNA | |
| SCHEMBL11279600 | 0.97 | ACHE (0.82) | ACHEMEN1SLC22A1ABCB11LMNA | |
| SCHEMBL11279602 | 0.97 | ACHE (0.82) | ACHEMEN1SLC22A1ABCB11LMNA | |
| SCHEMBL11250176 | 0.97 | ACHE (0.82) | ACHEMEN1SLC22A1ABCB11LMNA | |
| SCHEMBL11244714 | 0.94 | ACHE (0.84) | ACHEMEN1SLC22A1ABCB11LMNA | |
| SCHEMBL11244717 | 0.94 | ACHE (0.84) | ACHEMEN1SLC22A1ABCB11LMNA | |
| SCHEMBL11259744 | 0.93 | ACHE (0.90) | ACHEMEN1SLC22A1ABCB11LMNA | |
| SCHEMBL11264757 | 0.93 | ACHE (0.90) | ACHEMEN1SLC22A1ABCB11LMNA | |
| SCHEMBL11248127 | 0.93 | ACHE (0.90) | ACHEMEN1SLC22A1ABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317819-A | Amine derivatives | GLAXO GROUP LIMITED (GB) | 1982-03-02 | — | — | US | disclosed |
| US-4264614-A | HISTAMINE ANTAGONIST; ANTIALLERGENS; ANTISECRETORY AND ANTIINFLAMMATORY AGENTS | GLAXO GROUP LIMITED (GB) | 1981-04-28 | — | — | US | disclosed |