SCHEMBL11248683

SCHEMBL11248683

Brc1cccc(Br)c1N=C1N=CCN1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 1/20 0.31
PARP11 Q9NR21 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7609599 0.79 DYRK3 (0.34)
SCHEMBL7920726 0.75
SCHEMBL11591230 0.73 MEN1 (0.35)
SCHEMBL4716982 0.67 PARP10 (0.35) PARP10PARP11
SCHEMBL31123055 0.67 TRPA1 (0.33) PARP10PARP11
SCHEMBL11251790 0.64 PARP10 (0.33) PARP10PARP11
SCHEMBL11068818 0.64 KIF11 (0.30)
SCHEMBL31037906 0.62 PARP10 (0.35) PARP10PARP11
SCHEMBL31037912 0.62 PARP10 (0.35) PARP10PARP11
SCHEMBL31546236 0.61 PARP10 (0.34) PARP10PARP11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0006451-B1 IMIDAZO (1,2-A) IMIDAZOLES, THEIR ACID ADDITION SALTS, MEDICAMENTS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION C.H. BOEHRINGER SOHN (DE) 1982-04-14 EP disclosed
US-4210659-A BRADYCARDIACS BOEHRINGER INGELHEIM GMBH (DE) 1980-07-01 US disclosed
EP-0006451-A1 Imidazo (1,2-a) imidazoles, their acid addition salts, medicaments containing them and process for their preparation C.H. BOEHRINGER SOHN (DE) 1980-01-09 EP disclosed