Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Penicillamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.78 |
| ▸ | GABRP | O00591 | 2/20 | 0.41 |
| ▸ | GABRD | O14764 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.41 |
| ▸ | GABRE | P78334 | 2/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Penicillamine SCHEMBL4344 | 0.89 | — | — | |
| Penicillamine SCHEMBL4343 | 0.89 | — | — | |
| Dl-Penicillamine SCHEMBL22322162 | 0.89 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1GRIK1SLC1A3 | |
| Penicillamine SCHEMBL603349 | 0.89 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1GRIK1SLC1A3 | |
| Dl-Penicillamine SCHEMBL159653 | 0.89 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1GRIK1SLC1A3 | |
| Penicillamine SCHEMBL129296 | 0.89 | ALDH1A1 (1.00) | ALDH1A1MAPTPTGS1GRIK1SLC1A3 | |
| Dl-Penicillamine SCHEMBL57527 | 0.89 | — | — | |
| Dl-Penicillamine SCHEMBL2319399 | 0.87 | ALDH1A1 (0.78) | ALDH1A1MAPTPTGS1GABRPGABRD | |
| Penicillamine SCHEMBL2329725 | 0.87 | ALDH1A1 (0.78) | ALDH1A1MAPTPTGS1GABRPGABRD | |
| Glutamic Acid SCHEMBL4261156 | 0.87 | GRM8 (0.64) | ALDH1A1MAPTPTGS1GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351914-A | EPOXY RESIN, POLYHYDROXY COMPOUND, POLYAMINE OR POLYACID | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-09-28 | — | — | US | claimed |
| US-4351914-A | EPOXY RESIN, POLYHYDROXY COMPOUND, POLYAMINE OR POLYACID | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-09-28 | — | — | US | disclosed |