Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263019 | 0.90 | HTT (0.56) | HTTPOLBMEN1KMT2AMAPK1 | |
| SCHEMBL11055632 | 0.88 | HTT (0.59) | HTTPOLBMEN1KMT2AMAPK1 | |
| SCHEMBL11258517 | 0.85 | HTT (0.53) | HTTMEN1KMT2AMAPK1NPC1 | |
| SCHEMBL11250658 | 0.85 | HTT (0.60) | HTTPOLBMEN1KMT2AMAPK1 | |
| SCHEMBL11250046 | 0.84 | NPC1 (0.46) | HTTPOLBMEN1KMT2AMAPK1 | |
| SCHEMBL11053290 | 0.84 | HTT (0.52) | HTTPOLBMEN1KMT2AMAPK1 | |
| SCHEMBL11252801 | 0.83 | HTT (0.77) | HTTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL11255985 | 0.83 | HTT (0.50) | HTTMEN1KMT2AMAPK1NPC1 | |
| SCHEMBL11258017 | 0.82 | IMPDH2 (0.50) | HTTPOLBMEN1KMT2ANPC1 | |
| SCHEMBL11054939 | 0.82 | HTT (0.56) | HTTPOLBMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |