Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11705626 | 0.83 | SLC6A4 (0.65) | LMNASLC6A4HTR1AHTR3ASLC6A2 | |
| SCHEMBL11287076 | 0.81 | APOBEC3G (0.53) | LMNASLC6A4HTR1AHTR3ASLC6A2 | |
| SCHEMBL12462599 | 0.81 | SLC6A4 (0.47) | LMNASLC6A4HTR1AHTR3ASLC6A2 | |
| Hydrochloric Acid SCHEMBL8530226 | 0.80 | CYP2C9 (0.59) | LMNASLC6A4SLC6A2SLC6A3SMN1; SMN2 | |
| SCHEMBL30548760 | 0.80 | HTR1A (0.51) | LMNASLC6A4HTR1AHTR3ASLC6A2 | |
| SCHEMBL5250559 | 0.80 | SLC6A4 (0.42) | LMNASLC6A4SLC6A2SLC6A3CHRNA7 | |
| SCHEMBL11704531 | 0.79 | AGBL2 (0.46) | SLC6A4SLC6A2SLC6A3HPGDCHRNA7 | |
| SCHEMBL11481374 | 0.78 | SLC6A4 (0.43) | SLC6A4HTR1AHTR3ASLC6A2SLC6A3 | |
| SCHEMBL11761184 | 0.77 | ATM (0.46) | SLC6A4CYP2C9HPGDCYP2C19MEN1 | |
| SCHEMBL11759797 | 0.77 | MEN1 (0.44) | SLC6A4HTR1AHTR3ACYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013424-B1 | SPIRO(DIBENZO(B,F)THIEPINE-PIPERIDINES), INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-17 | — | — | EP | disclosed |
| EP-0013424-A1 | Spiro(dibenzo(b,f)thiepine-piperidines), intermediate products for their preparation and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-07-23 | — | — | EP | disclosed |
| US-4198420-A | Spiro[dibenz(b,f)thiepin-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |
| US-4198419-A | Phenylthiophenylpiperidines | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |