Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.50 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.50 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992264 | 0.80 | MAPK1 (0.51) | NPC1KMT2AMAPK1CYP4F2CYP4A11 | |
| SCHEMBL11238983 | 0.79 | MAPT (0.71) | MAPTALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL2773071 | 0.78 | PPARA (0.59) | MAPTALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL11249609 | 0.76 | PLK1 (0.46) | ALDH1A1L3MBTL1SMN1; SMN2EGFRMAPK1 | |
| SCHEMBL11251685 | 0.76 | PLK1 (0.46) | ALDH1A1L3MBTL1SMN1; SMN2EGFRMAPK1 | |
| SCHEMBL2186694 | 0.76 | EGFR (0.50) | MAPTKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL11695717 | 0.75 | TSHR (0.52) | ALDH1A1NPC1L3MBTL1GAAKMT2A | |
| SCHEMBL16318414 | 0.75 | NPC1 (0.56) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL10771374 | 0.74 | MAPT (0.62) | MAPTALDH1A1RAB9AL3MBTL1GAA | |
| SCHEMBL25263361 | 0.74 | MAPT (0.61) | MAPTALDH1A1RAB9AGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4333940-A | Ring-fluorinated 4-(monosubstituted-amino) phenyl compounds in inhibiting atherosclerotic lesion development | AMERICAN CYANAMID COMPANY (US) | 1982-06-08 | — | — | US | disclosed |
| US-4243609-A | ANTILIPEMIC AGENTS, ANTIATHEROSCLEROTIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| EP-0003663-A2 | Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1979-08-22 | — | — | EP | disclosed |