SCHEMBL11250352

SCHEMBL11250352

OC(C#CI)(c1ccccc1)c1ccc(C(F)(F)F)c(Cl)c1

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.36
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
PDE2A O00408 2/20 0.33
FAAH O00519 1/20 0.33
ALDH1A1 P00352 3/20 0.33
KMO O15229 2/20 0.33
MRGPRX4 Q96LA9 1/20 0.32
GRM4 Q14833 1/20 0.32
NOTUM Q6P988 2/20 0.32
GLA P06280 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11048505 0.76 ALDH1A1 (0.47) ALDH1A1TSHR
SCHEMBL11256138 0.73 CYP19A1 (0.40) CYP19A1ALDH1A1
SCHEMBL11261677 0.72 TSHR (0.43) CYP19A1CYP3A4TSHR
SCHEMBL11258403 0.72 CYP19A1 (0.50) CYP19A1CYP3A4TSHR
SCHEMBL11249211 0.71 CYP19A1 (0.40) CYP19A1CYP3A4CYP2D6ALDH1A1TSHR
SCHEMBL11252164 0.71 CCR6 (0.48) CYP3A4ALDH1A1TSHR
SCHEMBL11250427 0.70 KCNN4 (0.49) CYP19A1CYP3A4ALDH1A1
SCHEMBL11258472 0.69 MEN1 (0.46) CYP19A1TSHR
SCHEMBL11599290 0.69 TSHR (0.58) CYP3A4PDE2AALDH1A1KMOMRGPRX4
SCHEMBL3789260 0.69 PDE2A (0.56) PDE2AALDH1A1KMOMRGPRX4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4322442-A INSECTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1982-03-30 US claimed