Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11837143 | 0.88 | LMNA (0.33) | KDM4EPOLBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11091857 | 0.86 | CYP1A2 (0.42) | CYP1A2KDM4EPOLBALDH1A1MAPT | |
| SCHEMBL5933181 | 0.84 | KDM4E (0.45) | CYP1A2KDM4EPOLBALDH1A1MAPT | |
| SCHEMBL11253044 | 0.82 | MAPT (0.56) | CYP1A2KDM4EPOLBALDH1A1MAPT | |
| SCHEMBL11259908 | 0.82 | CYP1A2 (0.36) | CYP1A2KDM4EPOLBALDH1A1MAPT | |
| SCHEMBL11260929 | 0.81 | KMT2A (0.50) | KDM4EPOLBALDH1A1MAPTLMNA | |
| SCHEMBL11579747 | 0.79 | RAB9A (0.51) | CYP1A2KDM4EPOLBALDH1A1MAPT | |
| SCHEMBL11261135 | 0.78 | CYP1A2 (0.34) | CYP1A2POLB | |
| SCHEMBL4108632 | 0.78 | MEN1 (0.56) | CYP1A2KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11093462 | 0.78 | CYP1A2 (0.40) | CYP1A2KDM4EALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |