SCHEMBL11250798

SCHEMBL11250798

N#CCc1cn(-c2ccccc2)nc1-c1ccc(F)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.62
MAPT P10636 2/20 0.62
NPSR1 Q6W5P4 2/20 0.62
HTT P42858 2/20 0.62
LMNA P02545 1/20 0.62
XBP1 P17861 1/20 0.62
MAPK1 P28482 1/20 0.62
KDM4E B2RXH2 3/20 0.57
USP2 O75604 1/20 0.57
HPGD P15428 1/20 0.57
HSD17B10 Q99714 1/20 0.57
CCNE1 P24864 4/20 0.57
CDK2 P24941 4/20 0.57
POLB P06746 1/20 0.54
MAOB P27338 1/20 0.54
AGTR1 P30556 1/20 0.53
PTGS2 P35354 2/20 0.52
MEN1 O00255 3/20 0.51
KMT2A Q03164 3/20 0.51
NPC1 O15118 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11255300 0.95 ALDH1A1 (0.55) ALDH1A1MAPTNPSR1HTTLMNA
SCHEMBL11240095 0.90 KDM4E (0.60) ALDH1A1MAPTNPSR1HTTLMNA
SCHEMBL11245692 0.86 RAB9A (0.69) ALDH1A1MAPTNPSR1HTTKDM4E
SCHEMBL11247047 0.86 KDM4E (0.64) ALDH1A1MAPTNPSR1KDM4EUSP2
SCHEMBL11249486 0.86 KMT2A (0.69) ALDH1A1MAPTNPSR1HTTLMNA
SCHEMBL11256945 0.83 RAB9A (0.71) ALDH1A1MAPTNPSR1HTTMAPK1
SCHEMBL11540126 0.83 MAPT (0.53) ALDH1A1MAPTNPSR1HTTLMNA
SCHEMBL11250829 0.82 ALDH1A1 (0.85) ALDH1A1MAPTNPSR1HTTLMNA
SCHEMBL29528283 0.82 ALDH1A1 (0.66) ALDH1A1MAPTNPSR1HTTLMNA
SCHEMBL11247644 0.82 CA1 (0.53) ALDH1A1MAPTNPSR1HTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4325962-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIDYRETICS BYK-GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1982-04-20 US disclosed
US-4146721-A ANALGESICS, ANTIINFLAMMATORY AGENTS AND ANTIPYRETICS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1979-03-27 US disclosed