Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11255436 | 0.86 | GAA (0.50) | GAAALDH1A1ALOX15ALOX5PTGS1 | |
| SCHEMBL11260529 | 0.85 | GAA (0.48) | GAAALDH1A1ALOX15ALOX5PTGS1 | |
| SCHEMBL11263577 | 0.83 | GAA (0.47) | GAAALDH1A1ALOX15ALOX5PTGS1 | |
| SCHEMBL11500212 | 0.82 | GAA (0.47) | GAAALDH1A1ALOX15ALOX5PTGS1 | |
| SCHEMBL11250723 | 0.80 | GAA (0.44) | GAAALDH1A1ALOX15ALOX5PTGS1 | |
| SCHEMBL30819801 | 0.72 | GAA (0.53) | GAAALDH1A1ALOX15ALOX5PTGS1 | |
| SCHEMBL11266222 | 0.71 | GAA (0.48) | GAAALDH1A1ALOX15MAPK1CYP1A2 | |
| SCHEMBL13094665 | 0.71 | MEN1 (0.49) | ALDH1A1ALOX15ALOX5PTGS1LMNA | |
| SCHEMBL10426523 | 0.69 | ALOX5 (0.45) | ALDH1A1ALOX5PTGS1ESR1LMNA | |
| SCHEMBL11265814 | 0.67 | SMN1; SMN2 (0.51) | GAAALDH1A1ALOX15ALOX5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015523-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR MEDICAMENTS | Dr. Karl Thomae GmbH (DE) | 1982-10-13 | — | — | EP | disclosed |
| US-4343811-A | ATHEROSCLEROSIS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-10 | — | — | US | disclosed |
| EP-0015523-A1 | Indole derivatives, their preparation and their use for medicaments | Dr. Karl Thomae GmbH (DE) | 1980-09-17 | — | — | EP | disclosed |