Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.37 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250723 | 0.81 | GAA (0.44) | GAAALDH1A1ALOX15MAPK1ALOX5 | |
| SCHEMBL11255436 | 0.81 | GAA (0.50) | GAAALDH1A1ALOX15MAPK1ALOX5 | |
| SCHEMBL11260529 | 0.80 | GAA (0.48) | GAAALDH1A1ALOX15MAPK1ALOX5 | |
| SCHEMBL11500212 | 0.77 | GAA (0.47) | GAAALDH1A1ALOX15MAPK1ALOX5 | |
| SCHEMBL11264505 | 0.69 | GAA (0.41) | GAAALDH1A1ALOX15CYP2C9LMNA | |
| SCHEMBL21158689 | 0.67 | HTR2A (0.39) | TGFBR1THRBMAPK14KMT2AHTT | |
| SCHEMBL12743756 | 0.64 | TGFBR1 (0.35) | GAAALDH1A1TGFBR1MAPK1KMT2A | |
| SCHEMBL569668 | 0.64 | ALOX5 (0.44) | TGFBR1ALOX5THRBMAPK14 | |
| SCHEMBL23926385 | 0.63 | ADORA3 (0.39) | GAAALDH1A1TGFBR1MAPK1METAP1 | |
| SCHEMBL6068182 | 0.62 | KDM1A (0.54) | ALDH1A1ALOX15MAPK1ALOX5METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015523-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR MEDICAMENTS | Dr. Karl Thomae GmbH (DE) | 1982-10-13 | — | — | EP | disclosed |
| US-4343811-A | ATHEROSCLEROSIS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-10 | — | — | US | disclosed |
| EP-0015523-A1 | Indole derivatives, their preparation and their use for medicaments | Dr. Karl Thomae GmbH (DE) | 1980-09-17 | — | — | EP | disclosed |