Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.46 |
| ▸ | PRMT3 | O60678 | 4/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.44 |
| ▸ | TERT | O14746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15844207 | 0.89 | NOTUM (0.42) | NOTUMPRMT3ROCK2ROCK1IMPDH2 | |
| SCHEMBL113082 | 0.85 | ROCK2 (0.52) | NOTUMPRMT3ROCK2ROCK1IMPDH2 | |
| SCHEMBL16056718 | 0.84 | ROCK2 (0.56) | NOTUMPRMT3ROCK2ROCK1IMPDH2 | |
| SCHEMBL115009 | 0.83 | ROCK2 (0.53) | NOTUMPRMT3ROCK2ROCK1IMPDH2 | |
| SCHEMBL114094 | 0.81 | LTA4H (0.49) | NOTUMROCK2ROCK1IMPDH2 | |
| SCHEMBL112926 | 0.80 | NOTUM (0.51) | NOTUMPRMT3ROCK2ROCK1IMPDH2 | |
| SCHEMBL113436 | 0.78 | IMPDH2 (0.47) | NOTUMPRMT3ROCK2ROCK1IMPDH2 | |
| SCHEMBL2779492 | 0.76 | ROCK2 (0.46) | NOTUMPRMT3ROCK2IMPDH2TERT | |
| SCHEMBL16040568 | 0.76 | ROCK2 (0.49) | NOTUMPRMT3ROCK2ROCK1IMPDH2 | |
| SCHEMBL2776089 | 0.75 | ROCK2 (0.47) | NOTUMPRMT3ROCK2ROCK1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424842-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | Aerie Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| EP-2424857-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | Aerie Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010127329-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126626-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010127330-A1 | DUAL-ACTION INHIBITORS AND METHODS OF USING SAME | AERIE PHAMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |