Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 3/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.32 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23142695 | 0.92 | MGLL (0.34) | EEF2KCCR5 | |
| Hydrochloric Acid SCHEMBL142027 | 0.92 | MGLL (0.34) | EEF2KCCR5 | |
| SCHEMBL141305 | 0.90 | MGLL (0.35) | EEF2K | |
| SCHEMBL16887393 | 0.88 | EEF2K (0.39) | EEF2KCA1CA2CCR5SPHK1 | |
| SCHEMBL16887396 | 0.88 | EEF2K (0.39) | EEF2KCA1CA2CCR5SPHK1 | |
| SCHEMBL7585200 | 0.86 | CA1 (0.33) | EEF2KCA1CA2CCR5SPHK1 | |
| SCHEMBL7591943 | 0.85 | EEF2K (0.43) | EEF2KCA1CA2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11779798 | 0.84 | EEF2K (0.45) | EEF2KCCR5SPHK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11781058 | 0.84 | EEF2K (0.39) | EEF2KCCR5SPHK1MEN1KMT2A | |
| SCHEMBL9314254 | 0.84 | MGLL (0.34) | EEF2K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4331167-A | COMPRISING A METHYLPOLYSILOXANE OR PARAFFIN, A CATIONIC COMPOUND AND AN IMIDAZOLINE | WELLA AKTIENGESELLSCHAFT (DE) | 1982-05-25 | — | — | US | claimed |