SCHEMBL11253406

SCHEMBL11253406

ON=Cc1ccc(Cl)cc1CC1CO1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 6/20 0.41
TSHR P16473 2/20 0.41
MAPT P10636 7/20 0.39
KDM4E B2RXH2 2/20 0.38
ACHE P22303 4/20 0.37
HTT P42858 4/20 0.36
MEN1 O00255 3/20 0.36
CYP3A4 P08684 3/20 0.36
KMT2A Q03164 3/20 0.36
LMNA P02545 3/20 0.36
CYP1A2 P05177 2/20 0.36
CYP2D6 P10635 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36
POLB P06746 1/20 0.36
ALPG P10696 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
ALDH1A1 P00352 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6122179 0.80 USP2 (0.32) HPGDMAPTHTTMEN1CYP3A4
SCHEMBL11267314 0.78 HPGD (0.40) HPGDTSHRMAPTHTTMEN1
SCHEMBL24500618 0.76 HPGD (0.57) HPGDTSHRMAPTKDM4EHTT
SCHEMBL24182458 0.72 PTGDR (0.46) HPGDTSHRMAPTKDM4EHTT
SCHEMBL16881403 0.69 HPGD (0.51) HPGDTSHRMAPTKDM4EHTT
SCHEMBL16881404 0.69 HPGD (0.51) HPGDTSHRMAPTKDM4EHTT
SCHEMBL17861347 0.69 HPGD (0.51) HPGDTSHRMAPTKDM4EHTT
SCHEMBL2904656 0.68 MAPT (0.59) HPGDTSHRMAPTKDM4EHTT
SCHEMBL2904660 0.68 MAPT (0.59) HPGDTSHRMAPTKDM4EHTT
SCHEMBL4049047 0.68 MAPT (0.59) HPGDTSHRMAPTKDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4358450-A FOR DECREASING BLOOD CHOLESTEROL HOECHST AKTIENGESELLSCHAFT (DE) 1982-11-09 US disclosed