SCHEMBL11253758

SCHEMBL11253758

C=C(C)C(=O)N(Sc1c(C)cccc1C)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.34
MEN1 O00255 4/20 0.34
TSHR P16473 2/20 0.34
ALDH1A1 P00352 6/20 0.33
KDM4E B2RXH2 3/20 0.33
MYC P01106 1/20 0.33
NPSR1 Q6W5P4 2/20 0.32
HPGD P15428 3/20 0.32
HSD17B10 Q99714 2/20 0.32
GLA P06280 1/20 0.32
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CRHBP P24387 1/20 0.31
CRHR2 Q13324 1/20 0.31
POLB P06746 1/20 0.31
MTNR1A P48039 1/20 0.31
MTNR1B P49286 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11252915 0.80 ALDH1A1 (0.38) TSHRALDH1A1KDM4ENPSR1HPGD
SCHEMBL11245673 0.78 NPSR1 (0.42) KMT2AMEN1TSHRALDH1A1KDM4E
SCHEMBL11249078 0.78 ALDH1A1 (0.41) KMT2AMEN1TSHRALDH1A1KDM4E
SCHEMBL10351366 0.74 SMN1; SMN2 (0.36) TSHRALDH1A1KDM4ENPSR1HPGD
SCHEMBL11298575 0.73 MEN1 (0.37) KMT2AMEN1TSHRALDH1A1NPSR1
SCHEMBL11250213 0.72 ALDH1A1 (0.39) TSHRALDH1A1KDM4EHPGDGLA
SCHEMBL11244321 0.72 ALDH1A1 (0.39) KMT2AMEN1TSHRALDH1A1KDM4E
SCHEMBL11241076 0.71 SMN1; SMN2 (0.36) KMT2AMEN1TSHRALDH1A1NPSR1
SCHEMBL195179 0.70 NPSR1 (0.54) KMT2AMEN1TSHRALDH1A1KDM4E
SCHEMBL11253803 0.70 PKM (0.38) KMT2AMEN1TSHRALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4311648-A VULCANIZATION INHIBITION MONSANTO COMPANY (US) 1982-01-19 US disclosed
US-4291141-A INHIBITORS OF PREMATURE VULCANIZATION OF DIENES MONSANTO COMPANY (US) 1981-09-22 US disclosed