Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 5/20 | 0.58 |
| ▸ | HTR2C | P28335 | 3/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HLA-A | P04439 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11252759 | 0.99 | DRD2 (0.57) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL11394275 | 0.90 | DRD2 (0.62) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| Bromide SCHEMBL11259055 | 0.90 | DRD2 (0.55) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11249377 | 0.89 | DRD2 (0.49) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11302698 | 0.88 | DRD2 (0.47) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11254297 | 0.87 | DRD2 (0.49) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11301666 | 0.84 | DRD2 (0.51) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11247140 | 0.83 | DRD2 (0.58) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| Bromide SCHEMBL11249107 | 0.82 | DRD2 (0.57) | DRD2SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL11316484 | 0.79 | HTR2A (0.40) | DRD2SIGMAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016261-B1 | SPIRO(DIBENZ(B,F)OXEPIN-PIPERIDINES) AND METHODS OF PREPARING SAME | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-12-29 | — | — | EP | claimed |
| EP-0016261-A1 | Spiro(dibenz(b,f)oxepin-piperidines) and methods of preparing same | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-01 | — | — | EP | claimed |
| US-4198418-A | ANALGESICS, TRANQUILIZERS, ANTICONVULSANTS | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | claimed |
| EP-0016261-A1 | Spiro(dibenz(b,f)oxepin-piperidines) and methods of preparing same | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-01 | — | — | EP | disclosed |