Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11488069 | 0.99 | HTR2A (0.39) | HTR2AHRH1OPRM1OPRL1MAPT | |
| Bromide SCHEMBL11318175 | 0.87 | HTR2A (0.54) | HTR2AHRH1OPRM1MAPTNPSR1 | |
| Bromide SCHEMBL11476443 | 0.84 | SIGMAR1 (0.53) | HTR2AOPRM1MAPTLMNASIGMAR1 | |
| SCHEMBL11258495 | 0.83 | SETD7 (0.47) | HTR2AHRH1OPRM1SIGMAR1HTR2C | |
| Bromide SCHEMBL11253158 | 0.82 | SETD7 (0.46) | HTR2AHRH1OPRM1SIGMAR1HTR2C | |
| SCHEMBL11249377 | 0.81 | DRD2 (0.49) | HTR2AHRH1MAPTSIGMAR1HTR2C | |
| Bromide SCHEMBL11490261 | 0.81 | SMN1; SMN2 (0.44) | HTR2AHRH1MAPTSIGMAR1DRD2 | |
| Bromide SCHEMBL11255909 | 0.81 | OPRL1 (0.48) | HTR2AHRH1OPRM1OPRL1SIGMAR1 | |
| Bromide SCHEMBL11478623 | 0.81 | SIGMAR1 (0.46) | HTR2AHRH1CCR1SIGMAR1DRD2 | |
| SCHEMBL11254154 | 0.79 | DRD2 (0.58) | HTR2AHRH1OPRM1LMNASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016261-B1 | SPIRO(DIBENZ(B,F)OXEPIN-PIPERIDINES) AND METHODS OF PREPARING SAME | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-12-29 | — | — | EP | disclosed |
| EP-0016261-A1 | Spiro(dibenz(b,f)oxepin-piperidines) and methods of preparing same | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-01 | — | — | EP | disclosed |