Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254297 | 0.90 | DRD2 (0.49) | DRD2SIGMAR1HTR2AHTR2BHTR2C | |
| SCHEMBL11254154 | 0.89 | DRD2 (0.58) | DRD2SIGMAR1HTR2AHTR2BHTR2C | |
| Bromide SCHEMBL11252759 | 0.88 | DRD2 (0.57) | DRD2SIGMAR1HTR2AHTR2BHTR2C | |
| SCHEMBL11316484 | 0.81 | HTR2A (0.40) | DRD2SIGMAR1HTR2AHTR2BHTR2C | |
| Bromide SCHEMBL11488069 | 0.80 | HTR2A (0.39) | DRD2SIGMAR1HTR2AHTR2BHTR2C | |
| Bromide SCHEMBL11259055 | 0.79 | DRD2 (0.55) | DRD2SIGMAR1HTR2AHTR2BHTR2C | |
| Bromide SCHEMBL11490261 | 0.79 | SMN1; SMN2 (0.44) | DRD2SIGMAR1HTR2ADRD3KDM4E | |
| SCHEMBL11302698 | 0.79 | DRD2 (0.47) | DRD2SIGMAR1HTR2AHTR2BHTR2C | |
| Bromide SCHEMBL11476443 | 0.78 | SIGMAR1 (0.53) | DRD2SIGMAR1HTR2AHTR2BHTR2C | |
| Hydrochloric Acid SCHEMBL11394275 | 0.78 | DRD2 (0.62) | DRD2SIGMAR1HTR2AHTR2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016261-B1 | SPIRO(DIBENZ(B,F)OXEPIN-PIPERIDINES) AND METHODS OF PREPARING SAME | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-12-29 | — | — | EP | disclosed |
| EP-0016261-A1 | Spiro(dibenz(b,f)oxepin-piperidines) and methods of preparing same | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-01 | — | — | EP | disclosed |