SCHEMBL11255003

SCHEMBL11255003

Nc1ccc2c(c1)C(=O)OC2N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.42
RAB9A P51151 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
ALDH1A1 P00352 2/20 0.42
CYP3A4 P08684 2/20 0.42
TP53 P04637 1/20 0.42
TSHR P16473 1/20 0.42
MAPK1 P28482 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
PTPRC P08575 2/20 0.41
LMNA P02545 2/20 0.41
MEN1 O00255 1/20 0.41
APAF1 O14727 1/20 0.41
TDP2 O95551 1/20 0.41
NSD2 O96028 1/20 0.41
PLA2G1B P04054 1/20 0.41
POLB P06746 1/20 0.41
CTSL P07711 1/20 0.41
HPGD P15428 1/20 0.41
ALOX12 P18054 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16513031 0.79 ALDH1A1 (0.41) NPC1RAB9ASMN1; SMN2ALDH1A1CYP3A4
SCHEMBL6670418 0.79 ALDH1A1 (0.41) NPC1RAB9ASMN1; SMN2ALDH1A1CYP3A4
SCHEMBL302169 0.77 ALDH1A1 (0.51) NPC1RAB9ASMN1; SMN2ALDH1A1CYP3A4
SCHEMBL868796 0.75 ALDH1A1 (0.53) NPC1SMN1; SMN2ALDH1A1TP53TDP1
SCHEMBL15189320 0.75 NPC1 (0.38) NPC1RAB9ASMN1; SMN2ALDH1A1CYP3A4
SCHEMBL11873892 0.74 S100A4 (0.46) NPC1RAB9AALDH1A1TP53MEN1
SCHEMBL17641329 0.71 ATM (0.40) NPC1RAB9ASMN1; SMN2ALDH1A1CYP3A4
SCHEMBL6741758 0.71 MAOB (0.57)
SCHEMBL17641334 0.71 MAOB (0.46) APEX1
SCHEMBL6741552 0.71 MAOB (0.57)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0003726-B1 SUBSTITUTED DIAMINOPHTHALIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS COLOUR FORMERS IN PRESSURE OR HEAT SENSITIVE RECORDING MATERIALS CIBA-GEIGY AG (CH) 1982-01-20 EP claimed
US-4291902-A PRESSURE- AND HEAT-SENSITIVE ELEMENTS; COPYING; COLORFASTNESS CIBA-GEIGY CORPORATION (US) 1981-09-29 US claimed
US-4191690-A COLOR FORMERS CIBA-GEIGY CORPORATION (US) 1980-03-04 US claimed
EP-0003726-A1 Substituted diaminophthalides, process for their preparation and their use as colour formers in pressure or heat sensitive recording materials CIBA-GEIGY AG (CH) 1979-09-05 EP claimed
EP-0003726-B1 SUBSTITUTED DIAMINOPHTHALIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS COLOUR FORMERS IN PRESSURE OR HEAT SENSITIVE RECORDING MATERIALS CIBA-GEIGY AG (CH) 1982-01-20 EP disclosed
US-4291902-A PRESSURE- AND HEAT-SENSITIVE ELEMENTS; COPYING; COLORFASTNESS CIBA-GEIGY CORPORATION (US) 1981-09-29 US disclosed
US-4291902-A PRESSURE- AND HEAT-SENSITIVE ELEMENTS; COPYING; COLORFASTNESS CIBA-GEIGY CORPORATION (US) 1981-09-29 US disclosed
US-4291902-A PRESSURE- AND HEAT-SENSITIVE ELEMENTS; COPYING; COLORFASTNESS CIBA-GEIGY CORPORATION (US) 1981-09-29 US disclosed
US-4191690-A COLOR FORMERS CIBA-GEIGY CORPORATION (US) 1980-03-04 US disclosed
US-4191690-A COLOR FORMERS CIBA-GEIGY CORPORATION (US) 1980-03-04 US disclosed
US-4191690-A COLOR FORMERS CIBA-GEIGY CORPORATION (US) 1980-03-04 US disclosed
EP-0003726-A1 Substituted diaminophthalides, process for their preparation and their use as colour formers in pressure or heat sensitive recording materials CIBA-GEIGY AG (CH) 1979-09-05 EP disclosed