Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 19/20 | 1.00 |
| ▸ | DRD4 | P21917 | 19/20 | 1.00 |
| ▸ | DRD2 | P14416 | 17/20 | 0.88 |
| ▸ | MEN1 | O00255 | 1/20 | 0.87 |
| ▸ | NPC1 | O15118 | 1/20 | 0.87 |
| ▸ | LMNA | P02545 | 1/20 | 0.87 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.87 |
| ▸ | HTR1A | P08908 | 1/20 | 0.87 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.87 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.87 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.87 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.87 |
| ▸ | TSHR | P16473 | 1/20 | 0.87 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.87 |
| ▸ | DRD1 | P21728 | 1/20 | 0.87 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.87 |
| ▸ | HTR2A | P28223 | 1/20 | 0.87 |
| ▸ | HTR2C | P28335 | 1/20 | 0.87 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11253588 | 0.93 | DRD3 (1.00) | DRD3DRD4DRD2MEN1NPC1 | |
| SCHEMBL29390168 | 0.93 | DRD3 (1.00) | DRD3DRD4DRD2MEN1NPC1 | |
| SCHEMBL11270827 | 0.84 | DRD3 (0.88) | DRD3DRD4DRD2MEN1NPC1 | |
| SCHEMBL11255288 | 0.83 | DRD3 (0.86) | DRD3DRD4DRD2MEN1NPC1 | |
| SCHEMBL14281099 | 0.81 | DRD4 (0.80) | DRD3DRD4DRD2MEN1NPC1 | |
| SCHEMBL16887885 | 0.79 | DRD4 (1.00) | DRD3DRD4DRD2MEN1NPC1 | |
| SCHEMBL29087358 | 0.78 | CCR3 (0.83) | DRD3DRD4DRD2OPRM1KMT2A | |
| SCHEMBL11261970 | 0.75 | DRD3 (1.00) | DRD3DRD4DRD2MEN1NPC1 | |
| SCHEMBL7943354 | 0.74 | DRD3 (0.58) | DRD3DRD4DRD2MEN1NPC1 | |
| SCHEMBL11254792 | 0.74 | DRD3 (0.72) | DRD3DRD4DRD2MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210024498-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | MEDICONNS SHANGHAI BIOPHARMACEUTICAL CO LTD (CN) | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024498-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | PRLHR, DRD2, AVPR2 | DRD3 38/4885DRD4 4/4885DRD2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.