SCHEMBL11255832

SCHEMBL11255832

Cc1cccc2c1CCN=C2c1ccc(Br)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.40
TSHR P16473 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
MAPK10 P53779 3/20 0.36
MAPK14 Q16539 1/20 0.36
PARP1 P09874 1/20 0.36
PARP10 Q53GL7 1/20 0.36
PARP11 Q9NR21 1/20 0.36
LSS P48449 1/20 0.35
GABRA1 P14867 1/20 0.34
GABRA5 P31644 1/20 0.34
GABRA2 P47869 1/20 0.34
GABRB2 P47870 1/20 0.34
ALDH1A1 P00352 3/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
LMNA P02545 1/20 0.34
CYP19A1 P11511 2/20 0.33
CYP11B1 P15538 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11271107 0.85 MAPK10 (0.44) MAPK10PARP1PARP10PARP11ALDH1A1
SCHEMBL11261829 0.85 BRD4 (0.45) NPC1TSHRRAB9ASMN1; SMN2MAPK10
SCHEMBL11251733 0.82 ALDH1A1 (0.53) MAPK10ALDH1A1MAOALMNA
SCHEMBL1011370 0.73 ALDH1A1 (0.47) PARP1PARP10PARP11ALDH1A1MAOA
SCHEMBL11259543 0.73 MAPK10 (0.42) MAPK10MAPK14
SCHEMBL8487986 0.70 NOS2 (0.52) TSHRPARP1PARP10PARP11ALDH1A1
SCHEMBL28176958 0.70 PARP1 (0.42) PARP1PARP10PARP11ALDH1A1CYP19A1
SCHEMBL28176951 0.70 PARP1 (0.42) PARP1PARP10PARP11ALDH1A1CYP19A1
SCHEMBL3056436 0.70 ENPP1 (0.37) PARP1PARP10PARP11ALDH1A1CYP11B1
SCHEMBL5467699 0.68 CYP2A6 (0.42) NPC1RAB9ASMN1; SMN2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4337256-A ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) 1982-06-29 US disclosed
EP-0013411-A1 Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them TEIKOKU HORMONE MFG. CO., LTD. (JP) 1980-07-23 EP disclosed