Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.45 |
| ▸ | DRD3 | P35462 | 7/20 | 0.45 |
| ▸ | HRH1 | P35367 | 7/20 | 0.45 |
| ▸ | DRD1 | P21728 | 4/20 | 0.45 |
| ▸ | DRD5 | P21918 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | HTR1A | P08908 | 5/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11243189 | 0.88 | SMN1; SMN2 (0.44) | DRD2DRD3HRH1HRH3HTR2A | |
| SCHEMBL11441053 | 0.84 | SIGMAR1 (0.53) | DRD2DRD3HRH1HTR2AHTR1A | |
| Bromide SCHEMBL11428282 | 0.83 | HTR2A (0.53) | DRD2DRD3HRH1DRD1HTR2A | |
| Bromide SCHEMBL11433552 | 0.83 | HTR2A (0.41) | DRD2DRD3HRH1DRD1HTR2A | |
| SCHEMBL11445219 | 0.83 | DRD2 (0.49) | DRD2DRD3HRH1HTR2AHTR1A | |
| SCHEMBL11255411 | 0.82 | HPGD (0.43) | DRD2DRD3HRH1DRD1DRD5 | |
| SCHEMBL11477246 | 0.81 | HRH1 (0.50) | DRD2DRD3HRH1HRH3HTR2A | |
| Bromide SCHEMBL11441013 | 0.81 | HPGD (0.42) | DRD2DRD3HRH1DRD1DRD5 | |
| SCHEMBL11247919 | 0.81 | HRH1 (0.48) | DRD2DRD3HRH1DRD1HTR2A | |
| Bromide SCHEMBL11258479 | 0.80 | HRH1 (0.47) | DRD2DRD3HRH1DRD1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013424-B1 | SPIRO(DIBENZO(B,F)THIEPINE-PIPERIDINES), INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-17 | — | — | EP | disclosed |
| EP-0013424-A1 | Spiro(dibenzo(b,f)thiepine-piperidines), intermediate products for their preparation and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-07-23 | — | — | EP | disclosed |
| US-4198420-A | Spiro[dibenz(b,f)thiepin-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |