Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | PLG | P00747 | 2/20 | 0.43 |
| ▸ | PLAT | P00750 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | FADS1 | O60427 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11253879 | 0.88 | PLAU (0.46) | PLAUF2F10PLGPLAT | |
| SCHEMBL4097426 | 0.86 | RAB9A (0.53) | RAB9ANPC1ALDH1A1KLK1KLK5 | |
| SCHEMBL4103669 | 0.82 | SLC2A1 (0.56) | RAB9ANPC1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6698612 | 0.82 | IDO1 (0.44) | PLAUF2F10PLGPLAT | |
| SCHEMBL11260056 | 0.82 | PLAU (0.43) | PLAURAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL11258941 | 0.82 | MAPT (0.39) | PLAUF2F10PLGPLAT | |
| SCHEMBL12889264 | 0.80 | PLAU (0.40) | PLAUF2F10PLGPLAT | |
| SCHEMBL11258517 | 0.80 | HTT (0.53) | PLAUF2F10PLGPLAT | |
| SCHEMBL11253702 | 0.79 | PLAU (0.46) | PLAURAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL11250207 | 0.79 | PLAU (0.36) | PLAUF2F10PLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |