SCHEMBL11257016

SCHEMBL11257016

CC(N)(CO)C(C)(O)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.43
KCNN4 O15554 1/20 0.41
MAPT P10636 1/20 0.41
KMT2A Q03164 1/20 0.41
CYP2C19 P33261 2/20 0.39
HIF1A Q16665 1/20 0.39
ALDH1A1 P00352 2/20 0.39
ALOX15 P16050 1/20 0.39
SLC6A2 P23975 1/20 0.39
KDM4E B2RXH2 2/20 0.38
ESR1 P03372 2/20 0.38
ESR2 Q92731 2/20 0.38
CYP1A2 P05177 2/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2D6 P10635 1/20 0.37
MAPK1 P28482 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
HSD11B1 P28845 1/20 0.36
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28979012 0.78 CYP2C19 (0.42) TAAR1MAPTKMT2ACYP2C19HIF1A
SCHEMBL744277 0.78 TAAR1 (0.50) TAAR1KCNN4MAPTKMT2ACYP2C19
SCHEMBL1455824 0.78 TAAR1 (0.50) TAAR1KCNN4MAPTKMT2ACYP2C19
SCHEMBL1456007 0.78 TAAR1 (0.50) TAAR1KCNN4MAPTKMT2ACYP2C19
SCHEMBL1617443 0.77 ALDH1A1 (0.52) TAAR1KCNN4MAPTKMT2ACYP2C19
Hydrochloric Acid SCHEMBL1455023 0.76 TAAR1 (0.48) TAAR1KCNN4MAPTKMT2ACYP2C19
Hydrochloric Acid SCHEMBL1439423 0.76 TAAR1 (0.48) TAAR1KCNN4MAPTKMT2ACYP2C19
SCHEMBL7192 0.73 CYP2C19 (0.47) TAAR1MAPTKMT2ACYP2C19HIF1A
SCHEMBL6472876 0.73 CYP2C19 (0.47) TAAR1MAPTKMT2ACYP2C19HIF1A
SCHEMBL6492862 0.73 CYP2C19 (0.47) TAAR1MAPTKMT2ACYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4337352-A SALT FORMATION WITH OPTICALLY ACTIVE AMINE BAYER AKTIENGESELLSCHAFT (DE) 1982-06-29 US claimed
US-4337352-A SALT FORMATION WITH OPTICALLY ACTIVE AMINE BAYER AKTIENGESELLSCHAFT (DE) 1982-06-29 US disclosed
EP-0001821-B1 RESOLUTION OF D,L-ALPHA-AMINO ACIDS AND SALTS USED THEREFOR RIEDEL-DE HAEN AKTIENGESELLSCHAFT (DE) 1981-04-29 EP disclosed
EP-0001821-A1 Resolution of D,L-alpha-amino acids and salts used therefor RIEDEL-DE HAEN AKTIENGESELLSCHAFT (DE) 1979-05-16 EP disclosed