Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6492862 | 1.00 | CYP2C19 (0.47) | CYP2C19HIF1AALDH1A1TAAR1ALOX15 | |
| SCHEMBL7192 | 1.00 | CYP2C19 (0.47) | CYP2C19HIF1AALDH1A1TAAR1ALOX15 | |
| SCHEMBL10813673 | 0.98 | CYP2C19 (0.46) | CYP2C19HIF1AALDH1A1TAAR1ALOX15 | |
| Sulfuric Acid SCHEMBL15206476 | 0.89 | CYP2C19 (0.53) | CYP2C19HIF1AALDH1A1TAAR1ALOX15 | |
| Terephthalic Acid SCHEMBL27798564 | 0.86 | RXRA (0.47) | CYP2C19HIF1AALDH1A1CYP1A2KMT2A | |
| SCHEMBL30697572 | 0.84 | CYP2C19 (0.40) | CYP2C19HIF1AALDH1A1TAAR1ALOX15 | |
| SCHEMBL3197683 | 0.82 | CYP2C19 (0.48) | CYP2C19HIF1AALDH1A1TAAR1ALOX15 | |
| SCHEMBL3190736 | 0.82 | CYP2C19 (0.48) | CYP2C19HIF1AALDH1A1TAAR1ALOX15 | |
| SCHEMBL957143 | 0.81 | CYP2C19 (0.44) | CYP2C19HIF1AALDH1A1TAAR1ALOX15 | |
| SCHEMBL24032604 | 0.80 | LMNA (0.50) | ALDH1A1ALOX15CYP1A2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12516065-B2 | Tertiary alcohols as PI3K-γ inhibitors | INCYTE CORPORATION (US) | 2026-01-06 | — | — | US | disclosed |
| US-20250388553-A1 | AMINOPYRAZINE DERIVATIVES AS PI3K-y INHIBITORS | INCYTE CORP (US) | 2025-12-25 | — | — | US | disclosed |
| US-20250313550-A1 | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS | INCYTE CORPORATION | 2025-10-09 | — | — | US | disclosed |
| US-12365668-B2 | Aminopyrazine diol compounds as PI3K-y inhibitors | INCYTE CORPORATION (US) | 2025-07-22 | — | — | US | disclosed |
| CN-119120399-A | Cytochrome P450 monooxygenase and application thereof in synthesis of chiral tertiary alcohol | 遵义医科大学 | 2024-12-13 | — | — | CN | disclosed |
| US-20240400541-A1 | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS | INCYTE CORPORATION | 2024-12-05 | — | — | US | disclosed |
| US-20240228498-A1 | TERTIARY ALCOHOLS AS PI3K-y INHIBITORS | INCYTE CORPORATION | 2024-07-11 | — | — | US | disclosed |
| CN-118290402-A | Aminopyrazine diol compounds as PI 3K-gamma inhibitors | 因赛特公司 | 2024-07-05 | — | — | CN | disclosed |
| US-12006320-B2 | Heterocyclic derivatives as PI3K inhibitors | INCYTE CORPORATION (US) | 2024-06-11 | — | — | US | disclosed |
| CN-118063470-A | Condensed imidazole derivatives substituted with tertiary hydroxyl groups as PI 3K-gamma inhibitors | 因赛特公司 | 2024-05-24 | — | — | CN | disclosed |
| EP-0641207-A1 | ENANTIOMERIC CYNEMICIN ANALOGS, PREPARATION AND USE THEREOF | THE SCRIPPS RESEARCH INSTITUTE (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0608307-A1 | NEW LIGANDS FOR ASYMMETRIC DIHYDROXYLATION: MULTIPLE CINCHONA ALKALOID UNITS ATTACHED TO A CENTRAL HETEROCYCLIC CORE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5302257-A | Preparing optically active glycols using catalyst complex of osmium tetroxide and chiral oxidation resistant tertiary amine, employing secondary oxidant to generate osmium tetroxide, electrolytically regenerating secondary oxidant | SEPRACOR, INC. (US) | 1994-04-12 | — | — | US | disclosed |
| US-5281710-A | Antibiotics or antitumor agents | THE SCRIPPS RESEARCH INSTITUTE (US) | 1994-01-25 | — | — | US | disclosed |
| WO-1993023046-A1 | ENANTIOMERIC CYNEMICIN ANALOGS, PREPARATION AND USE THEREOF | THE SCRIPPS RESEARCH INSTITUTE (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5260461-A | Asymmetric dihydroxylation of olefins, osmium tetraoxide stereoselective catalyst, enantiomers, ferricyanide salt | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1993-11-09 | — | — | US | disclosed |
| WO-1993017150-A1 | ELECTROCATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINIC COMPOUNDS | SEPRACOR, INC. (US) | 1993-09-02 | — | — | WO | disclosed |
| EP-0543969-A1 | HETEROCYCLIC CHIRAL LIGANDS AND METHOD FOR CATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1993-06-02 | — | — | EP | disclosed |
| WO-1993007142-A1 | NEW LIGANDS FOR ASYMMETRIC DIHYDROXYLATION: MULTIPLE CINCHONA ALKALOID UNITS ATTACHED TO A CENTRAL HETEROCYCLIC CORE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1993-04-15 | — | — | WO | disclosed |
| WO-1991016322-A2 | HETEROCYCLIC CHIRAL LIGANDS AND METHOD FOR CATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1991-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12006320-B2 | Heterocyclic derivatives as PI3K inhibitors | PIK3CD, PIK3R5, PIK3CA | CYP2C19 899/4885HIF1A 1625/4885ALDH1A1 2309/4885 |
| US-20240228498-A1 | TERTIARY ALCOHOLS AS PI3K-y INHIBITORS | PIK3R5, PIK3R1, PIK3CD | CYP2C19 2245/4885HIF1A 2000/4885ALDH1A1 333/4885 |
| US-20240400541-A1 | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS | PIK3CD, PIK3R5, PIK3CG | CYP2C19 1838/4885HIF1A 2605/4885ALDH1A1 2648/4885 |
| US-20250388553-A1 | AMINOPYRAZINE DERIVATIVES AS PI3K-y INHIBITORS | PIK3R5, PIK3R1, PIK3C2B | CYP2C19 4231/4885HIF1A 1797/4885ALDH1A1 3109/4885 |
| US-12365668-B2 | Aminopyrazine diol compounds as PI3K-y inhibitors | PIK3CD, PIK3R5, PIK3CG | CYP2C19 1838/4885HIF1A 2605/4885ALDH1A1 2648/4885 |
| US-20250313550-A1 | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS | PIK3CD, PIK3R5, PIK3CG | CYP2C19 1838/4885HIF1A 2605/4885ALDH1A1 2648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.