Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | USP14 | P54578 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clopirac SCHEMBL24768 | 0.77 | NOTUM (0.61) | POLBNOTUMMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12608916 | 0.77 | NOTUM (0.57) | POLBNOTUMMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11377279 | 0.76 | NOTUM (0.56) | POLBNOTUMMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19298013 | 0.75 | NOTUM (0.48) | POLBNOTUMMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2760337 | 0.72 | POLB (0.60) | POLBNOTUMMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16752445 | 0.70 | NOTUM (0.49) | POLBNOTUMMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL31380195 | 0.69 | POLB (0.56) | POLBNOTUMMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9786546 | 0.69 | NOTUM (0.54) | POLBNOTUMMAPK1ALDH1A1SMN1; SMN2 | |
| Clopirac SCHEMBL28121041 | 0.69 | NOTUM (0.51) | POLBNOTUMMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21225472 | 0.69 | ALDH1A1 (0.62) | POLBNOTUMALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362738-A | ANTIINFLAMMATORIES | DR. KARL THOMAE GMBH (DE) | 1982-12-07 | — | — | US | disclosed |