Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | USP14 | P54578 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11257155 | 0.75 | POLB (0.51) | NOTUMPOLBMAPK1ALDH1A1SMN1; SMN2 | |
| Clopirac SCHEMBL24768 | 0.74 | NOTUM (0.61) | NOTUMPOLBMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL12608916 | 0.74 | NOTUM (0.57) | NOTUMPOLBMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11377279 | 0.73 | NOTUM (0.56) | NOTUMPOLBMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2760337 | 0.72 | POLB (0.60) | NOTUMPOLBMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL18431149 | 0.70 | ALDH1A1 (0.66) | NOTUMPOLBMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL22454429 | 0.70 | ALDH1A1 (0.66) | NOTUMPOLBMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL31380195 | 0.69 | POLB (0.56) | NOTUMPOLBMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16752445 | 0.67 | NOTUM (0.49) | NOTUMPOLBMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2739319 | 0.67 | POLB (0.53) | NOTUMPOLBMAPK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170247355-A1 | PROTEOSTASIS REGULATORS | PROTEOSTASIS THERAPEUTICS, INC. | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247355-A1 | PROTEOSTASIS REGULATORS | PSMG3, VCP, HSPA5 | NOTUM 3292/4885POLB 2527/4885MAPK1 3492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.