Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | CDC25B | P30305 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5919605 | 0.81 | ELANE (0.63) | ELANEGABRA1GABRB2AKR1B1MAPK1 | |
| SCHEMBL9629402 | 0.79 | ELANE (0.70) | ELANEGABRA1GABRB2AKR1B1MAPK1 | |
| SCHEMBL11214361 | 0.79 | MEN1 (0.46) | ELANEGABRA1GABRB2MAPK1CYP3A4 | |
| SCHEMBL30497048 | 0.74 | ELANE (0.67) | ELANEGABRA1GABRB2AKR1B1MAPK1 | |
| SCHEMBL2834207 | 0.74 | ELANE (0.67) | ELANEGABRA1GABRB2AKR1B1MAPK1 | |
| SCHEMBL15676646 | 0.73 | GABRA1 (0.64) | ELANEGABRA1GABRB2AKR1B1MAPK1 | |
| Ammonia Solution, Strong SCHEMBL27806147 | 0.73 | ELANE (0.66) | ELANEGABRA1GABRB2AKR1B1MAPK1 | |
| SCHEMBL8425612 | 0.71 | ELANE (0.50) | ELANEGABRA1GABRB2AKR1B1MAPK1 | |
| SCHEMBL5299235 | 0.70 | CDC25B (0.58) | MAPK1CYP3A4HPGDALOX15KDM4E | |
| SCHEMBL30695845 | 0.70 | CDC25B (0.58) | MAPK1CYP3A4HPGDALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0036502-B1 | 2-ALKYL-5-HYDROXY-1,4-NAPHTHOQUINONES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS | ZYMA GMBH (DE) | 1983-10-19 | — | — | EP | disclosed |
| EP-0036502-A1 | 2-Alkyl-5-hydroxy-1,4-naphthoquinones, process for their manufacture and pharmaceutical preparations containing these compounds | ZYMA GMBH (DE) | 1981-09-30 | — | — | EP | disclosed |