Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7620197 | 0.76 | DRD1 (0.45) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11252603 | 0.75 | KDM4E (0.41) | ALDH1A1MAPTKDM4ETSHRMEN1 | |
| SCHEMBL11343586 | 0.72 | MAPT (0.43) | ALDH1A1MAPTKDM4ETSHRMEN1 | |
| SCHEMBL10655982 | 0.68 | CYP1A1 (0.38) | ALDH1A1MAPTTSHRKMT2ALMNA | |
| SCHEMBL7629632 | 0.67 | TUBB4A (0.50) | TSHRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7621171 | 0.63 | MAOB (0.53) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL7618224 | 0.63 | HDAC1 (0.45) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| Bromide SCHEMBL11460380 | 0.62 | POLB (0.35) | KDM4ELMNAHTT | |
| SCHEMBL13928826 | 0.62 | MAOA (0.51) | ALDH1A1MAPTKDM4ETSHRMEN1 | |
| SCHEMBL27757915 | 0.62 | DRD1 (0.52) | ALDH1A1KDM4ETSHRTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4359464-A | 3-Furylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines and antihypertensive use thereof | SMITHKLINE BECKMAN CORPORATION (US) | 1982-11-16 | — | — | US | disclosed |
| US-4352754-A | HYPOTENSIVE, ANTI-PARKINSON | SMITHKLINE CORPORATION (US) | 1982-10-05 | — | — | US | disclosed |
| US-4255422-A | DIURETICS, TREATMENT OF CARDIOVASCULAR DISORDERS | SMITHKLINE CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| US-4160765-A | Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds | SMITHKLINE CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |