Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11258510 | 0.81 | ABL1 (0.62) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL11258664 | 0.76 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL11258670 | 0.75 | ABL1 (0.69) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL27868475 | 0.70 | LMNA (0.49) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL11782292 | 0.68 | MGAM (0.46) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9148337 | 0.66 | LMNA (0.85) | NPC1RAB9ASMN1; SMN2LMNAALOX15 | |
| SCHEMBL29152812 | 0.65 | ALOX15 (0.49) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL6841863 | 0.64 | RIPK1 (0.48) | RIPK1PARP1PKN1PKN2PLK4 | |
| SCHEMBL11705968 | 0.63 | CYP2C9 (0.47) | NPC1RAB9AKDM4ELMNAALOX15 | |
| SCHEMBL11195206 | 0.63 | ALOX15 (0.62) | NPC1RAB9ASMN1; SMN2LMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4321393-A | Method for preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles | SMITHKLINE CORPORATION (US) | 1982-03-23 | — | — | US | disclosed |
| US-4285878-A | N-Phenyl-N'-cyano-O-phenylisoureas | SMITHKLINE CORPORATION (US) | 1981-08-25 | — | — | US | disclosed |