Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.48 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.48 |
| ▸ | CHRNG | P07510 | 4/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.48 |
| ▸ | CHRND | Q07001 | 4/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16860701 | 0.84 | GLRA1 (0.73) | GLRA1ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL22664709 | 0.81 | EGFR (0.58) | KDM4EALDH1A1GAASLC6A2CHRNB4 | |
| SCHEMBL22664708 | 0.80 | NPC1 (0.56) | KDM4EALDH1A1GAAMAOBEGFR | |
| SCHEMBL16860678 | 0.79 | GLRA1 (0.79) | GLRA1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL16860746 | 0.76 | GLRA1 (1.00) | GLRA1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL16860700 | 0.75 | GLRA1 (0.71) | GLRA1KDM4EALDH1A1GAAMEN1 | |
| SCHEMBL11258712 | 0.75 | SLC6A4 (0.51) | GLRA1KDM4EALDH1A1GAASLC6A2 | |
| SCHEMBL1072701 | 0.74 | SLC6A2 (0.69) | KDM4EALDH1A1GAASLC6A2CHRNB4 | |
| SCHEMBL18199242 | 0.74 | GLRA1 (1.00) | GLRA1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL24534624 | 0.73 | ALDH1A1 (0.49) | KDM4EALDH1A1GAASLC6A2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361573-A | α,α-Diaryl-β-(tert-amino)-propanols and diuretic pharmaceutical compositions containing them | TEMMLER AG (CH) | 1982-11-30 | — | — | US | disclosed |
| US-4025633-A | DIURETICS, SALURETICS | FIRMA TEMMLER A.G. (CH) | 1977-05-24 | — | — | US | disclosed |