Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | ACHE | P22303 | 5/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263177 | 0.98 | ALDH1A1 (0.62) | ALDH1A1ACHETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL9852931 | 0.83 | SLC6A4 (0.46) | ALDH1A1ACHESMN1; SMN2OPRL1 | |
| SCHEMBL3114045 | 0.83 | ALDH1A1 (0.67) | ALDH1A1ACHESMN1; SMN2OPRL1KDM4E | |
| SCHEMBL519228 | 0.81 | ALDH1A1 (0.69) | ALDH1A1ACHETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL3609859 | 0.79 | ALDH1A1 (0.66) | ALDH1A1ACHETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL15797283 | 0.79 | ALDH1A1 (0.70) | ALDH1A1ACHETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL18274490 | 0.79 | ALDH1A1 (0.56) | ALDH1A1ACHETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL18274493 | 0.78 | ALDH1A1 (0.64) | ALDH1A1ACHETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL18274459 | 0.78 | ALDH1A1 (0.59) | ALDH1A1ACHETSHRRAB9ASMN1; SMN2 | |
| SCHEMBL5606081 | 0.77 | ACHE (0.46) | ALDH1A1ACHETSHRRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337253-A | 4,5-Dihydro-2-methyl-6-(4-pyridinyl)-3(2H)-pyridazinone and its use as a cardiotonic | STERLING DRUG INC. (US) | 1982-06-29 | — | — | US | disclosed |