Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11260709 | 0.83 | KCNA5 (0.36) | MEN1KMT2AHTTCYP3A4CYP2D6 | |
| SCHEMBL11253547 | 0.82 | HTT (0.36) | MEN1KMT2AHTTCYP3A4CYP2D6 | |
| SCHEMBL11264980 | 0.79 | MEN1 (0.41) | MEN1KMT2AHTTCYP3A4CYP2D6 | |
| SCHEMBL11259393 | 0.78 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2NPSR1RAB9AL3MBTL1 | |
| SCHEMBL364905 | 0.78 | KCNA5 (0.50) | CYP3A4CYP2D6CYP2C19KCNA5ALDH1A1 | |
| SCHEMBL11268090 | 0.73 | GLRA1 (0.39) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL11258069 | 0.72 | KCNA5 (0.39) | MEN1KMT2ACYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11257390 | 0.72 | MEN1 (0.34) | MEN1KMT2AHTTCYP3A4CYP2D6 | |
| SCHEMBL12890839 | 0.71 | KCNA5 (0.52) | CYP3A4CYP2D6CYP2C19KCNA5ALDH1A1 | |
| SCHEMBL11251766 | 0.70 | P4HB (0.36) | MEN1KMT2AHTTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361573-A | α,α-Diaryl-β-(tert-amino)-propanols and diuretic pharmaceutical compositions containing them | TEMMLER AG (CH) | 1982-11-30 | — | — | US | disclosed |
| US-4025633-A | DIURETICS, SALURETICS | FIRMA TEMMLER A.G. (CH) | 1977-05-24 | — | — | US | disclosed |