Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | APP | P05067 | 5/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11259609 | 0.73 | MEN1 (0.41) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL11264980 | 0.72 | MEN1 (0.41) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11258699 | 0.68 | GLRA1 (0.61) | GLRA1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11260709 | 0.66 | KCNA5 (0.36) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL16860701 | 0.65 | GLRA1 (0.73) | GLRA1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL11253547 | 0.65 | HTT (0.36) | MEN1KMT2AALDH1A1TP53MAPT | |
| SCHEMBL11258936 | 0.65 | KCNA5 (0.33) | MEN1KMT2A | |
| SCHEMBL13957662 | 0.64 | MAPT (0.50) | GLRA1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL11259393 | 0.64 | ALDH1A1 (0.37) | RAB9AKDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL11258069 | 0.63 | KCNA5 (0.39) | MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361573-A | α,α-Diaryl-β-(tert-amino)-propanols and diuretic pharmaceutical compositions containing them | TEMMLER AG (CH) | 1982-11-30 | — | — | US | claimed |