Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | PRKCA | P17252 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11260207 | 0.87 | TDP1 (0.35) | L3MBTL1TDP1FLT3AURKAJAK2 | |
| SCHEMBL11252606 | 0.85 | TDP1 (0.44) | KDM4EMAPTL3MBTL1TDP1HTT | |
| SCHEMBL11266460 | 0.84 | CDK5 (0.38) | KDM4EL3MBTL1TDP1UTS2RHTT | |
| SCHEMBL11269174 | 0.83 | TDP1 (0.45) | KDM4EMAPTL3MBTL1TDP1HTT | |
| SCHEMBL11251784 | 0.83 | CAMKK2 (0.35) | LMNAMAPTTSHRL3MBTL1TDP1 | |
| SCHEMBL11251508 | 0.81 | CAMKK2 (0.36) | MAPTTSHRL3MBTL1TDP1FLT3 | |
| SCHEMBL11267832 | 0.80 | TDP1 (0.45) | KDM4EMAPTTDP1CHRNA7GSK3B | |
| SCHEMBL31364004 | 0.79 | TDP1 (0.49) | MAPTL3MBTL1TDP1FLT3AURKA | |
| SCHEMBL11263232 | 0.79 | PKM (0.40) | KDM4ELMNAMAPTTSHRL3MBTL1 | |
| SCHEMBL11255892 | 0.78 | CAMKK2 (0.34) | MAPTNPC1RAB9ASMN1; SMN2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |