SCHEMBL11260460

SCHEMBL11260460

CC(C)=CCS(=O)(=O)c1ccc(C)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSK P43235 1/20 0.56
ALDH1A1 P00352 7/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
KMT2A Q03164 2/20 0.50
MEN1 O00255 1/20 0.50
MMP1 P03956 2/20 0.48
MMP9 P14780 2/20 0.48
MMP13 P45452 2/20 0.48
TLR9 Q9NR96 1/20 0.45
GAA P10253 1/20 0.45
RECQL P46063 1/20 0.45
MAPT P10636 2/20 0.44
ADAM17 P78536 1/20 0.44
DHODH Q02127 1/20 0.43
PKM P14618 2/20 0.43
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
MMP2 P08253 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6263113 0.85 TRPV1 (0.51) CTSKALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL6263109 0.85 TRPV1 (0.51) CTSKALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL31678748 0.85 TRPV1 (0.51) CTSKALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL9419767 0.84 TRPV1 (0.50) CTSKALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL11484335 0.84 TRPV1 (0.50) CTSKALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL10405653 0.84 TRPV1 (0.50) CTSKALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL9770419 0.84 TRPV1 (0.50) CTSKALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL10405654 0.84 TRPV1 (0.50) CTSKALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL7758163 0.82 PSIP1 (0.54) ALDH1A1KMT2AMEN1MAPTTP53
SCHEMBL7511102 0.82 CTSK (0.50) CTSKALDH1A1CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4343952-A SULFONATION OF DIENE WITH SULFINATE, PALLADIUM CATALYST AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (ANVAR) (FR) 1982-08-10 US disclosed
US-4206140-A INSECTICIDES, ANTHELMINTICS ROUSSEL UCLAF (FR) 1980-06-03 US disclosed
US-4199531-A Intermediates for the production of quinones TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1980-04-22 US disclosed
US-4101574-A Cyclopropanecarboxylic acid chlorides ROUSSEL UCLAF (FR) 1978-07-18 US disclosed
US-3997586-A Cyclopropanecarboxylic acids and esters ROUSSEL-UCLAF (FR) 1976-12-14 US disclosed