Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9465417 | 0.82 | TSHR (0.41) | TSHRGABRA1LMNAALDH1A1GABRB2 | |
| SCHEMBL11719990 | 0.80 | TSHR (0.44) | TSHRGABRA1GABRG2GABRB3OPRM1 | |
| SCHEMBL11273817 | 0.80 | TSHR (0.35) | TSHRGABRA1LMNAALDH1A1CYP1A2 | |
| SCHEMBL11262186 | 0.79 | GABRA1 (0.43) | TSHRAPOBEC3GGABRA1GABRG2GABRB3 | |
| SCHEMBL12981697 | 0.79 | TSHR (0.42) | TSHRAPOBEC3GGABRA1GABRG2GABRB3 | |
| SCHEMBL357875 | 0.78 | TSHR (0.61) | TSHRAPOBEC3GGABRA1GABRG2GABRB3 | |
| SCHEMBL9463681 | 0.78 | LMNA (0.48) | TSHRAPOBEC3GGABRA1GABRG2GABRB3 | |
| SCHEMBL357956 | 0.74 | GABRA1 (0.58) | TSHRAPOBEC3GGABRA1GABRG2GABRB3 | |
| SCHEMBL8857876 | 0.73 | APOBEC3G (0.46) | TSHRAPOBEC3GGABRA1GABRG2GABRB3 | |
| SCHEMBL27945798 | 0.73 | CYSLTR2 (0.40) | TSHRAPOBEC3GGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351842-A | N-Cyclopropylisoindolines | GLAXO LABORATORIES LIMITED (GB) | 1982-09-28 | — | — | US | disclosed |