Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 4/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | PTPRF | P10586 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPRB | P23467 | 1/20 | 0.37 |
| ▸ | PTPRE | P23469 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11278409 | 0.85 | LMNA (0.42) | LMNAUGT2B7PDE2ACYP2D6CYP1A2 | |
| SCHEMBL22288132 | 0.81 | LMNA (0.42) | LMNAUGT2B7PDE2ACYP2D6CYP1A2 | |
| SCHEMBL5107130 | 0.80 | LMNA (0.61) | LMNAPDE2ACYP2D6TSHRAOC3 | |
| SCHEMBL5107136 | 0.80 | LMNA (0.61) | LMNAPDE2ACYP2D6TSHRAOC3 | |
| SCHEMBL30172716 | 0.80 | LMNA (0.61) | LMNAPDE2ACYP2D6TSHRAOC3 | |
| SCHEMBL5107133 | 0.80 | LMNA (0.61) | LMNAPDE2ACYP2D6TSHRAOC3 | |
| SCHEMBL10120474 | 0.77 | UGT2B7 (0.62) | LMNAUGT2B7CYP2D6CYP1A2TSHR | |
| SCHEMBL3929537 | 0.77 | CYP2C9 (0.50) | LMNACYP1A2TSHRKMT2AAOC3 | |
| SCHEMBL483715 | 0.77 | UGT2B7 (0.62) | LMNAUGT2B7CYP2D6CYP1A2TSHR | |
| SCHEMBL3418792 | 0.77 | CYP2C9 (0.50) | LMNACYP1A2TSHRKMT2AAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351842-A | N-Cyclopropylisoindolines | GLAXO LABORATORIES LIMITED (GB) | 1982-09-28 | — | — | US | disclosed |